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Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism.

In stimulating the body's adaptive immunity , they help prevent sickness from an infectious disease. When a sufficiently large percentage of a population has been vaccinated, herd immunity results. Herd immunity protects those who may be immunocompromised and cannot get a vaccine because even a weakened version would harm them.

However, some diseases, such as measles outbreaks in America, have seen rising cases due to relatively low vaccination rates in the s — attributed, in part, to vaccine hesitancy.

The first disease people tried to prevent by inoculation was most likely smallpox, with the first recorded use of variolation occurring in the 16th century in China. He was the first to publish evidence that it was effective and to provide advice on its production. The immunization was called vaccination because it was derived from a virus affecting cows Latin : vacca 'cow'.