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The cerebellum is thought to participate in the regulation of movement and is comprised of various types of neurons in the cerebellar cortex and nuclei. Each type of neurons has morphologically, immunohistochemically, and electrophysiologically distinct characteristics. In addition, there are two precerebellar afferent systems, the mossy fiber MF system and the climbing fiber CF system.

MF neurons are located in various nuclei throughout the brainstem and send their axons to cerebellar granule cells, whereas CF neurons reside exclusively in the inferior olivary nucleus ION and project to Purkinje cells. Recently developed genetic lineage-tracing methods as well as gene-transfer technologies have accelerated the studies on the molecular machinery to specify neuronal subtypes in the cerebellum and the precerebellar systems.

This is a preview of subscription content, log in via an institution to check access. Institutional subscriptions. J Comp Neurol — Ambrosiani J, Armengol JA, Martinez S, Puelles L The avian inferior olive derives from the alar neuroepithelium of the rhombomeres 7 and 8: an analysis by using chick-quail chimeric embryos. Neuroreport — J Neurosci — Nature — Development — Neuron — Cambronero F, Puelles L Rostrocaudal nuclear relationships in the avian medulla oblongata: a fate map with quail chick chimeras.

Carletti B, Rossi F Neurogenesis in the cerebellum. Neuroscientist — Article PubMed Google Scholar. Exp Brain Res — Mol Genet Metab — Dev Biol — Cerebellum — Eur J Neurosci — Dev Cell — Mol Brain Ivanova A, Yuasa S Neuronal migration and differentiation in the development of the mouse dorsal cochlear nucleus. Dev Neurosci — Jankovski A, Rossi F, Sotelo C Neuronal precursors in the postnatal mouse cerebellum are fully committed cells: evidence from heterochronic transplantations.