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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Bionanocapsules BNCs are hollow nanoparticles consisting of hepatitis B virus HBV envelope L proteins and have been shown to deliver drugs and genes specifically to human hepatic tissues by utilizing HBV-derived infection machinery.
In this study, under acidic conditions and high temperature, BNCs were found to fully fuse with LPs smooth-surfaced spherical form , deploying L proteins with a membrane topology similar to that of BNCs ie, virosomes displaying L proteins.
Doxorubicin DOX was efficiently encapsulated via the remote loading method at Furthermore, the virosomes preferentially delivered DOX to the nuclei of human hepatic cells. Xenograft mice harboring either target or nontarget cell-derived tumors were injected twice intravenously with the virosomes containing DOX at a low dose 2. The growth of target cell-derived tumors was retarded effectively and specifically. Next, the combination of high dose These results demonstrated that the HBV-based virosomes containing DOX could be an effective antitumor nanomedicine specific to human hepatic tissues, especially in combination with radiotherapy.
Nanoparticles NPs including liposomes LPs , polymers, and micelles have been expected as promising drug delivery system DDS nanocarriers for cancer chemotherapy. For example, NPs modified with folic acid or transferrin were shown to accumulate efficiently in tumors expressing receptors for each ligand.