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The serum adiponectin concentrations were measured by a radioimmunoassay. In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort. John Wikstrand. JinHa Yoon. Bo Hedblad. Background— Circulating adiponectin is a marker for insulin sensitivity, derived from fat cells. It is largely unknown if adiponectin is also an independent marker for early atherosclerosis.

Methods and Results— Plasma adiponectin levels were measured in men and women of middle-age by a time-resolved immunofluorometric assay.

An ultrasound measurement of the right common carotid artery intima media thickness IMT was made. When the distribution of adiponectin was stratified into sex-specific quartiles Q1 to Q4 , men in Q4 differed from Q1 in higher mean age and high-density lipoprotein HDL cholesterol, but lower blood pressure, HbA 1c , HOMA-index, and body mass index.