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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.
In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Osteoarthritis OA is a progressive and irreversible degenerative joint disease that is characterized by cartilage destruction, osteophyte formation, subchondral bone remodeling, and synovitis. Despite affecting millions of patients, effective and safe disease-modifying osteoarthritis drugs are lacking. Here we reveal an unexpected role for the small molecule 5-aminosalicylic acid 5-ASA , which is used as an anti-inflammatory drug in ulcerative colitis.
Intra-articular 5-ASA injections ameliorate OA generated by surgery-induced medial-meniscus destabilization in male mice. Moreover, mice with DMM-induced OA that are treated with 5-ASA at weeks 8—11 and sacrificed at week 12 have thicker cartilage than untreated mice that were sacrificed at week 8.
Osteoarthritis OA is an age-related chronic degenerative joint disease that is characterized by cartilage destruction, osteophyte formation, subchondral-bone remodeling, and synovitis 1. Although it is the most common degenerative joint disease globally and a leading cause of disability and reduced quality-of-life in older people 2 , therapeutic options mainly involve pain management 3.