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Clinical trials have demonstrated that adding zoledronic acid Zol to neo adjuvant standard of care has differential antitumour effects in pre- and post-menopausal women: Both benefit from reduced recurrence in bone; however, while postmenopausal women also incur survival benefit, none is seen in premenopausal women treated with adjuvant bisphosphonates.

In the current study, we have used mouse models to investigate the role of oestradiol in modulating potential antitumour effects of Zol.

Supplementing ovariectomised mice with Osteoclast activity was increased 1. Zol increased trabecular bone in all groups but did not restore bone to volumes observed under premenopausal conditions.

In contrast, Zol significantly reduced soft tissue metastases 2. In conclusion, oestradiol contributes to altered antitumour effects of Zol observed between pre- and post-menopausal women. Keywords: bone microenvironment; breast cancer; menopause; oestradiol; zoledronic acid. Abstract Clinical trials have demonstrated that adding zoledronic acid Zol to neo adjuvant standard of care has differential antitumour effects in pre- and post-menopausal women: Both benefit from reduced recurrence in bone; however, while postmenopausal women also incur survival benefit, none is seen in premenopausal women treated with adjuvant bisphosphonates.

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