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Metrics details. Lung cancer has been the leading cause of cancer-related mortality worldwide among both men and women in recent years. There is an increase in the incidence of nonsmoking-related lung cancer in recent years. The purpose of the present study was to investigate multiple potential risk factors for nonsmoking-related lung cancer among Asian Ethnic Groups. We used a propensity score-mated cohort analysis for this study. Clinical information and nodule characteristics were recorded.
A propensity score-mated cohort analysis was applied to adjust for potential bias and to create two comparable groups according to family history of lung cancer. For our primary analysis, we matched pairs of subjects with family history of lung cancer and subjects without history. In conclusion, risk-based prediction model based on the family history of lung cancer and female gender can potentially improve efficiency of lung cancer screening programs in Taiwan. Peer Review reports. Lung cancer has been the leading cause of cancer-related mortality worldwide among both men and women in recent years [ 1 , 2 , 3 ].
Smoking is the major risk factor for lung cancer, but an increase in the incidence of nonsmoking-related lung cancer in recent years has been addressed [ 4 , 5 , 6 , 7 , 8 ]. There has been an increase in the prevalence of non-smoking associated lung cancers in Asian countries such as China, Taiwan, Korea, and Japan over the past few years [ 9 , 10 ].
Previous studies suggested that a potential association among nonsmokers who had lung adenocarcinoma with associated risk factors such as age, gender, body mass index BMI , history of lung cancer, and personal cancer history [ 8 , 11 ]. A major concern has remained regarding that selection bias that occurs as a result of self-referral or physician referral in the setting of these studies designs, which is ordinarily considered a threat to both internal and external validity of the studies [ 8 , 11 ].
