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Aging Albany NY. We conducted a 4-year longitudinal follow-up study, recruited AD and 44 mild cognitive impairment MCI patients, and used a data-driven trajectory analysis to examine the influence of selected AD risk genes on the age for and the rate of cognitive decline in Han Chinese population. The rate of cognitive decline varies substantially among different AD patients. There are many factors that contribute to the rate of cognitive decline, such as age of disease onset, gender, education, extrapyramidal signs, behavioral disorders, vascular risk factors and the most known AD susceptibility genetic locus, apolipoprotein E APOE genotypes [ 1 , 2 ].

Among these factors, genetic background is one of the most important contributors to the rate of cognitive decline. However, some evidence has revealed that these risk genes may act differently in different populations.

For example, in a meta-analysis, AD was significantly associated with variants in ABCA7 in African American participants and with other genes that have been associated with AD in individuals of European ancestry [ 6 ]. In a study validating genome-wide association studies GWAS -identified risk loci based on Caucasians populations showed that not all of these risk loci were linked to the risk of AD in Han Chinese populations [ 8 ].

Hence, the effect of genetic factors on the rate of cognitive decline should be addressed in different ethnic groups [ 10 ]. However, most of these studies have conducted in Caucasian population and data about the genetics of AD from other populations has been relatively limited [ 10 ]. In Han Chinese or Asian population, common variants in GCH1 , KCNJ15 [ 19 ], and rare missense variant in the C7 genes [ 20 ] were also identified by whole-genome sequencing and whole-exome sequencing studies.