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DOI: E-mail: ezgikar comu. Aim: The role of inflammatory mechanisms in the formation of insulin resistance IR , diabetes and metabolic syndrome has been widely discussed in recent years.

Material and Methods: Four hundred fifteen adult patients whose samples were accepted to the laboratory between the hours of ; leukocyte, neu- trophil and lymphocyte count, mean platelet volume MPV , insulin, glucose, and cortisol levels were examined retrospectively. All data were statistically evaluated using the SPSS package program. However, there was no significant difference between the MPV levels. Although there was a negative correlation between cortisol with insulin and NLR levels, no significant correlation was found between cortisol and glucose, neutrophil-lymphocyte count.

Discussion: The significant increase in hematological inflammatory cells in patients with IR suggests that inflammatory mechanisms may have produced insulin resistance. The increase in insulin levels and suppression of cortisol levels may play a role in the progression of inflammation. Diabetes mellitus DM is a chronic, broad-spectrum metabolic disorder, which requires constant medical care, and the organism cannot benefit enough carbohydrate, fat and proteins [1]. Inflammation can affect insulin signaling, indirectly increasing the risk of DM [9], and the increase of cytokines disrupts beta cell function [10].

Many studies confirm that increased hematological inflammatory markers especially WBC levels are an independent risk factor for insulin resistance, diabetes, metabolic syndrome, and coronary artery disease []. Both the types of malignancy and chronic diseases have been shown to be related to subclinical inflammation in various literature studies [14, 15]. Cortisol plays very important regulatory roles in glucose metabolism and plays an important role in the insulin signaling pathway.