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Official websites use. Share sensitive information only on official, secure websites. The search was supplemented with the Online Mendelian Inheritance in Man database.
Disease subtype and genetic mutations stratified patients with respect to age of presentation, aneurysmal location, and aortic diameter before dissection. Routine imaging and genetic testing of relatives of patients affected by nonsyndromic aortopathies should be encouraged.
TADs may be syndromic, associated with disorders involving other organs such as Marfan syndrome, or more commonly nonsyndromic, with manifestations restricted to the thoracic aorta. The data, analytic methods, and study materials are available to other researchers for purposes of reproducing the results or replicating the procedure Supplemental Material. Search criteria, adopted keywords, and MeSH terms used in relevant combinations are reported in Data S1.
Two investigators G. Discrepancies were resolved through consensus and consultation with a third investigator G. One reviewer extracted key data from the included studies using a standard dedicated pro forma; a second reviewer checked the collected data for completeness and accuracy.