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Sex and strain differences in renal hemodynamics in mice

Official websites use. Share sensitive information only on official, secure websites. Correspondence , Keisa W. Email: keisa. RBF was measured by a flow probe placed in the renal artery under an anesthetic state. Taken together, our study suggests that sex differences in renal hemodynamics in mice are strain and age dependent. Furthermore, the sexual dimorphism did not impact the severity of renal injury in diabetic nephropathy.

Keywords: glomerular filtration rate, renal blood flow, renal hemodynamics, sex, strain. There are sex and strain differences in renal hemodynamics, which may also be age dependent. The sex difference in renal hemodynamics is not attributed to eNOS, and do not impact the development of diabetic kidney disease.

It is increasingly recognized that interactions between biological, social, and environmental factors play a significant role in the prevention, pathophysiology, and management of human disease Mannon et al.

It is evident that there are sex differences in the incidence, age of onset, manifestation, severity and development, as well as response to treatment in various diseases, including heart disease, hypertension, obesity, and acute or chronic renal ischemia Arnold et al. In addition to sex differences, racial heterogeneity in renal function Hsu et al.

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