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Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults. Aging Albany NY. Associations of baseline plasma NFL concentrations or rate of change in plasma NFL with longitudinal data on other biomarkers were tested by multivariate linear mixed effects models LMEMs. Results showed that plasma NFL concentration and its rate of change were already abnormally high in the preclinical phase of AD.

In summary, these results indicated that baseline plasma NFL, but not its rate of change, may be a valuable noninvasive tool to assess neurodegeneration and predict longitudinal disease progression in preclinical AD individuals.

Based on this notion, current studies have divided the clinical stages of AD into three phases: preclinical phase, prodromal phase and dementia phase [ 6 ]. Among these phases, the most critical stage for early diagnosis and monitoring is the preclinical phase in which individuals are cognitively normal but have had pathological changes. However, none of these biomarkers is suited to track disease progression, because of their invasiveness or high expenses. Therefore, many studies focused on blood biomarkers, such as plasma neurofilament light NFL.

The NFL is a component of the axonal cytoskeleton and a putative marker of large-caliber axonal degeneration which is an important pathological change in neurodegeneration diseases [ 7 ]. Advancements in measurements of NFL have revealed the abnormal increase in the progression of AD, even in early stages.