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The association between constipation and cardiovascular risk is unclear. For each constipation admission, one exact age-matched non-constipated admission was randomly selected from all hospitalizations within 2 weeks to form the comparison cohort. The association of constipation with hypertension and cardiovascular events myocardial infarction, angina, stroke and transient ischemic attack were analysed using a series of binary logistic regressions adjusting for age, sex, cardiovascular risk factors, gastrointestinal disorders and sociological factors.
Patients with constipation had a higher multivariate-adjusted risk for hypertension odds ratio [OR], 1.
Compared to patients with neither constipation nor hypertension, there was a higher multivariate-adjusted risk for cardiovascular events in patients with constipation alone OR, 1. In patients with both constipation and hypertension, the risk for all cardiovascular events appeared to be additive OR, 6.